abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer death in the US. The protein kinase D (PKD) family has emerged as a promising target for cancer therapy with PKD1 being most intensively studied; however, its role in HNSCC has not been investigated. METHODS:The expression of...

journal_title：BMC cancer

authors： Zhang L,Li Z,Liu Y,Xu S,Tandon M,Appelboom B,LaValle CR,Chiosea SI,Wang L,Sen M,Lui VWY,Grandis JR,Wang QJ

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Survival rates of lung cancer remains poor and the impact of comorbidities on the prognosis is discussed. The objective of this study was to assess if the Charlson Comorbidity Index (CCI) was associated with 8-year survival rates by histological type. METHODS:A cohort study was conducted using randomly sele...

journal_title：BMC cancer

authors： Seigneurin A,Delafosse P,Trétarre B,Woronoff AS,Velten M,Grosclaude P,Guizard AV,Lapôtre-Ledoux B,Bara S,Molinié F,Colonna M

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various cancers including pancreatic cancer. METHODS:We investigated the anti tumor efficacy of triptolide in ...

journal_title：BMC cancer

authors： Kim ST,Kim SY,Lee J,Kim K,Park SH,Park YS,Lim HY,Kang WK,Park JO

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved for TNBC and cytotoxic agents remain the mainstay of treatment. Ixazomib is a selective and reversib...

journal_title：BMC cancer

authors： Rinnerthaler G,Gampenrieder SP,Petzer A,Burgstaller S,Fuchs D,Rossmann D,Balic M,Egle D,Rumpold H,Singer CF,Bartsch R,Petru E,Melchardt T,Ulmer H,Mlineritsch B,Greil R

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Up to 80% of breast cancer patients suffer from Cancer Related Cognitive Impairments (CRCI). Exercise is suggested as a potential supportive care option to reduce cognitive decline in cancer patients. This study will investigate the effects of a high-intensity interval endurance training (HIIT) on CRCI in br...

journal_title：BMC cancer

authors： Oberste M,Schaffrath N,Schmidt K,Bloch W,Jäger E,Steindorf K,Hartig P,Joisten N,Zimmer P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify the microRNAs related to the radiochemotherapy sensitivity in gastric cancer. METHODS:From April 201...

journal_title：BMC cancer

authors： Liu X,Cai H,Sheng W,Huang H,Long Z,Wang Y

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dialysis. The objective of the FASTRACK II clinical trial is to investigate the efficacy of SABR for pr...

journal_title：BMC cancer

authors： Siva S,Chesson B,Bressel M,Pryor D,Higgs B,Reynolds HM,Hardcastle N,Montgomery R,Vanneste B,Khoo V,Ruben J,Lau E,Hofman MS,De Abreu Lourenco R,Sridharan S,Brook NR,Martin J,Lawrentschuk N,Kron T,Foroudi F

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatment. The aim of this study is t...

journal_title：BMC cancer

authors： Johnston SJ,Ahmad D,Aleskandarany MA,Kurozumi S,Nolan CC,Diez-Rodriguez M,Green AR,Rakha EA

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care. METHODS:We searched academic and grey literature databases, and other sources for primary randomised controlled trials (RCT...

journal_title：BMC cancer

authors： Martínez-González NA,Neuner-Jehle S,Plate A,Rosemann T,Senn O

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung cancer in France, and to assess whether socioeconomic indicators were predictors of access at the leve...

journal_title：BMC cancer

authors： Scherpereel A,Durand-Zaleski I,Cotté FE,Fernandes J,Debieuvre D,Blein C,Gaudin AF,Tournier C,Vainchtock A,Chauvin P,Souquet PJ,Westeel V,Chouaïd C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS:The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL pa...

journal_title：BMC cancer

authors： Wu S,Zhou Y,Hua HY,Zhang Y,Zhu WY,Wang ZQ,Li J,Gao HQ,Wu XH,Lu TX,Hua D

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of ...

journal_title：BMC cancer

authors： Folyovich A,Varga V,Várallyay G,Kozák L,Bakos M,Scheidl E,Béres-Molnár KA,Kajdácsi Z,Bereczki D

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem. METHODS:We examined the efficacy of anti-PD-1/PD-L1 inhibitors after the discontinuation of antibodies ...

journal_title：BMC cancer

authors： Tachihara M,Negoro S,Inoue T,Tamiya M,Akazawa Y,Uenami T,Urata Y,Hattori Y,Hata A,Katakami N,Yokota S

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Biannual ultrasound (US)-with or without alpha-fetoprotein (AFP)-is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been a concern. Magnetic resonance imaging (MRI) is known to have high sensitivity in detecting hepatic m...

journal_title：BMC cancer

authors： An C,Kim DY,Choi JY,Han KH,Roh YH,Kim MJ

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). METHODS:A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were ...

journal_title：BMC cancer

authors： Wang RX,Chen S,Huang L,Shao ZM

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for this population, and compare its performance to a widely used overseas model, the Nottingham Prognosti...

journal_title：BMC cancer

authors： Elwood JM,Tawfiq E,TinTin S,Marshall RJ,Phung TM,Campbell I,Harvey V,Lawrenson R

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL is highly personalized and complex therapy. It requests substantial upfront investments from the hosp...

journal_title：BMC cancer

authors： Retèl VP,Steuten LMG,Geukes Foppen MH,Mewes JC,Lindenberg MA,Haanen JBAG,van Harten WH

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperative chemotherapy, postoperative chemoradiotherapy and postoperative chemotherapy. However, these reg...

journal_title：BMC cancer

authors： Slagter AE,Jansen EPM,van Laarhoven HWM,van Sandick JW,van Grieken NCT,Sikorska K,Cats A,Muller-Timmermans P,Hulshof MCCM,Boot H,Los M,Beerepoot LV,Peters FPJ,Hospers GAP,van Etten B,Hartgrink HH,van Berge Henegouwen MI,

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Sexually transmitted Human Papilloma Virus (HPV) infection is a known risk factor for cancer of the anal canal in both men and women. CASE PRESENTATION:We describe a report of synchronous carcinoma of the anal canal in a heterosexual couple. High risk type 16 HPV DNA was detected in both tumors. CONCLUSION...

journal_title：BMC cancer

authors： Mendez LC,Hsieh E,Earle CC,Wong S

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50-60 Gy irradiation in breast cancer. However, these agents are also often used clinically for the control of radiation dermatitis induced by high-dose (>60Gy) irradiation with chemotherapy in...

journal_title：BMC cancer

authors： Zenda S,Yamaguchi T,Yokota T,Miyaji T,Mashiko T,Tanaka M,Yonemura M,Takeno M,Okano T,Kawasaki T,Nakamori Y,Ishii S,Shimada S,Kanamaru M,Uchitomi Y

更新日期：2018-09-06 00:00:00

abstract：BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...

journal_title：BMC cancer

authors： Mohkam K,Rayar M,Adam JP,Muscari F,Rode A,Merle P,Pradat P,Bauler S,Delfour I,Chiche L,Ducerf C,Boudjema K,Lesurtel M,Laurent C,Mabrut JY

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already be...

journal_title：BMC cancer

authors： Fumet JD,Wickre M,Jacquot JP,Bizollon MH,Melis A,Vanoli A,Viel E

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT). METHODS:A total of 97 locally advanced ESCC patients were enrolled. All the patients had their ...

journal_title：BMC cancer

authors： Chen YH,Lu HI,Lo CM,Wang YM,Chou SY,Hsiao CC,Huang CC,Shih LH,Chen SW,Li SH

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification of responsive patients before the chemotherapy is initiated. We have demonstrated that doxorubicin ...

journal_title：BMC cancer

authors： Denard B,Jiang S,Peng Y,Ye J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:With the advent of novel drugs improved overall survival in patients with multiple myeloma, including patients who received up-front autologous stem cell transplantation (ASCT), has been reported from several centers. Here we report on overall survival in a population-based cohort of patients receiving ASCT ...

journal_title：BMC cancer

authors： Tangen JM,Tjønnfjord GE,Gulbrandsen N,Gedde-Dahl T,Stormorken E,Anderson K,Vo CD,Schjesvold FH,For Oslo Myeloma Center.

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expression and function of BAG3 in CRC. METHODS:BAG3 protein expression was evaluated in 90 CRC specimens us...

journal_title：BMC cancer

authors： Li N,Chen M,Cao Y,Li H,Zhao J,Zhai Z,Ren F,Li K

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. METHODS:A prospective, longitudinal, single-center study was conducted to assess the response t...

journal_title：BMC cancer

authors： Yu L,Wang H,Milijkovic D,Huang X,Jiang Q

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non-small cell lung cancer (NSCLC), especially in East Asian patients. We conducted this meta-analysis to compare their efficacy and safety in treatin...

journal_title：BMC cancer

authors： Zhang W,Wei Y,Yu D,Xu J,Peng J

更新日期：2018-08-02 00:00:00

abstract：BACKGROUND:Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal delirium in patients with gastric cancer is unknown. Here, we investigated the incidence and risk fac...

journal_title：BMC cancer

authors： Hwang H,Lee KM,Son KL,Jung D,Kim WH,Lee JY,Kong SH,Suh YS,Lee HJ,Yang HK,Hahm BJ

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL). METHODS:A systematic search of PubMed, Embase, and the Cochrane Library was conducted for relevant studies from database in...

journal_title：BMC cancer

authors： Shen Z,Gu X,Mao W,Yin L,Yang L,Zhang Z,Liu K,Wang L,Huang Y

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differen...

journal_title：BMC cancer

authors： Mogensen MB,Rossing M,Østrup O,Larsen PN,Heiberg Engel PJ,Jørgensen LN,Hogdall EV,Eriksen J,Ibsen P,Jess P,Grauslund M,Nielsen HJ,Nielsen FC,Vainer B,Osterlind K

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to induce oncolytic cell death in a variety of cancer cells of diverse origins. However, whether oncolyti...

journal_title：BMC cancer

authors： Jiang K,Song C,Kong L,Hu L,Lin G,Ye T,Yao G,Wang Y,Chen H,Cheng W,Barr MP,Liu Q,Zhang G,Ding C,Meng S

更新日期：2018-07-18 00:00:00

abstract：BACKGROUD:The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN nodal metastases in esophageal cancer patients. METHODS:Sixty patients with esophageal cancer underwen...

journal_title：BMC cancer

authors： Wang J,Liu M,Shen J,Ouyang H,Xie X,Lin T,Li A,Yang H

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the...

journal_title：BMC cancer

authors： McEvoy AC,Warburton L,Al-Ogaili Z,Celliers L,Calapre L,Pereira MR,Khattak MA,Meniawy TM,Millward M,Ziman M,Gray ES

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna si...

journal_title：BMC cancer

authors： Hwang-Bo J,Bae MG,Park JH,Chung IS

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:The purpose of this case report is to describe a conjunctiva and eyelid Kaposi's sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. CAS...

journal_title：BMC cancer

authors： Sousa Neves F,Braga J,Cardoso da Costa J,Sequeira J,Prazeres S

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the outcomes of current approaches necessitate an ongoing evaluation of the epidemiology and mortality-tre...

journal_title：BMC cancer

authors： Saad AM,Turk T,Al-Husseini MJ,Abdel-Rahman O

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specif...

journal_title：BMC cancer

authors： Xiao J,Egger ME,McMasters KM,Hao H

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:RECQL is a number of the RecQ DNA helicase family and plays an important role in maintaining genome stability. Although several studies have reported that RECQL mutations were correlated with the susceptibility to breast cancer, the effect on prognosis in breast cancer was not yet clarified. Here, we explore...

journal_title：BMC cancer

authors： Xu H,Xu Y,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis. METHODS:We constructed p300 down-regula...

journal_title：BMC cancer

authors： Hou X,Gong R,Zhan J,Zhou T,Ma Y,Zhao Y,Zhang Y,Chen G,Zhang Z,Ma S,Chen X,Gao F,Hong S,Luo F,Fang W,Yang Y,Huang Y,Chen L,Yang H,Zhang L

更新日期：2018-06-07 00:00:00